The 3 Biggest ‘General Hospital’ Moments You Can’t Miss – Week of December 22-26
General Hospital spoilers reveal three must-see moments for the week of December 22, 2025. Fans can expect Monica Quartermaine (Lesley Charleson) to be remembered.
Ava Jerome (Maura West) learns two significant pieces of information. Plus, Jenz Sidwell (Carlo Rota) hosts a party at Wyndemere. Keep reading, and let’s talk about what is coming up in the ABC soap opera.
Christmas Joy & Sadness
Let’s start off with the Christmas holiday. For one thing, the soap will be preempted on Christmas Day. However, we will see Jason Morgan (Steve Burton) and Danny Morgan (Asher Antonyzyn) distributing gifts.
Meanwhile, Tracy Quartermaine (Jane Elliott) has a moment where she misses Monica.
Ava Jerome’s Double Discovery
Another must-see moment includes Ava. First, the woman makes up with Nina Reeves (Cynthia Watros). Nina will tell her friend about a new deal to save Willow Tait Cain (Katelyn MacMullen).
This includes Nina working for Jack Brennan (Chris McKenna) targeting Charlotte Cassadine (Bluesy Burke) to get to Valentin Cassadine (James Patrick Stuart). I was thankful that Nina warned Charlotte not to trust anyone with the information, not even her.
A bit later in the week, Ava will learn another piece of information. This one centers on Portia Robinson (Brook Kerr). It’s interesting the female friendships that we have seen lately, and I’m all for it!
Jenz Sidwell’s Soiree
Over at Wyndemere, Pascal (Eric Forget) is Sidwell’s butler. However, he’s also taking care of a hostage: Anna Devane (Finola Hughes).
While she is being held captive, Anna is also incredibly resourceful. The woman also used to be in the WSB as well as being a police commissioner.
So, she could find a way to get out of there. However, I wonder if her escape will coincide with Sidwell’s soiree at the estate.
Will Anna come stumbling out during Sidwell’s party?! That certainly would make it an unforgettable event!
Kevin Collins’ Thankful
That also leads Kevin Collins (Jon Linstrom) to be thankful. If Anna escapes and it happens at Sidwell’s party, it could be just enough leverage for Laura Collins (Genie Francis) and Sonny Corinthos (Maurice Benard) to get out of their deal.
Willow Tait Cain’s Trial
General Hospital spoilers reveal that another must-see moment is what happens at Willow Tait Cain’s (Katelyn MacMullen) trial. It seems this case isn’t getting more answers; it’s just getting more complicated as time goes on.
Will Nina’s plan work, or could Willow go down anyway?
Which storyline are you looking forward to seeing the most during the week of December 22, 2025? Share your thoughts in the comment section below. Keep watching the soap on ABC to find out what happens next.
